Foundation Neuroprotection

Multidimensional Brain & Nervous System Support

Ceralin® Forte is formulated to provide well-rounded support for brain and nerve protection, addressing multiple pathways involved in neurological health. Designed to act within the brain and nervous system, this advanced formula features significant levels of grape seed extract, 5-methyl tetrahydrofolate, N-acetylcysteine (NAC), and acetyl-L-carnitine.

Suggested Nutritional Supplementation

• Ceralin Forte® - Three capsules daily.

Ceralin Forte is formulated to provide well-rounded support for brain and nerve protection, addressing multiple pathways involved in neurological health.

• Appropriate Wellness EssentialsTM formula - 1-2 packets daily

Key Vitamins & Minerals, Essential Fatty Acids, PLUS Patient Specific Nutrition.

Patient benefits:

• Supports healthy cognitive function, possibly by enhancing cellular energy dynamics
• Provides potent antioxidant protection for the central nervous system
• Supports a healthy life cycle of neurons and other cells
• May protect the blood-brain barrier and nerve cells from oxidative stress

Helps maintain overall neurological health by supporting healthy mitochondrial function, methylation, homocysteine

metabolism, and circulatory function

Recommended uses:

• Multidimensional neuroprotection support
• Cerebrovascular support

CAUTION: Do not use if pregnant for nursing. If patient is taking medication-including anticoagulants- use with caution.

Refrences:

1.        Abdul HM, Calabrese V, Calvani M, et al. Acetyl-L-carnitineinduced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease. J Neurosci Res 2006;84(2):398-408.

2.        Zanelli SA, Solenski MJ, Rosenthal RE, et al. Mechanisms of ischemic neuroprotection by acetyl-L-carnitine. Ann NY Acad Sci 2005;1053:153-61.

3.        Inano A, Sai Y, Nikaido H, et al. Acetyl-L-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2. Biopharm Drug Dispos 2003;24(8):357-65.

4.        Mackenzie GG, Zago MP, Erlejman AG, et al. Alpha-lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-kappaB and AP-1 transcription factors in human neuroblastoma IMR-32 cells. Free Radic Res 2006;40(1):75-84.

5.        Monks TJ, Ghersi-Egea JF, Philbert M, et al. Symposium overview: the role of glutathione in neuroprotection and neurotoxicity. Toxicol Sci 1999;51:161-77.

6.        Hwang IK, Yoo KY, Kim DS, et al. Neuroprotective effects of grape seed extract on neuronal injury by inhibiting DNA damage in the gerbil hippocampus after transient forebrain ischemia. Life Sci 204;75:1989-2001.

7.        Lin Y, Desbois A, Jiang S, et al. Group B vitamins protect murine cerebellar granule cells from glutamate/NMDA toxicity. Neuropharmacol Neurotoxicol 2004;15;2241-44.

8.        Coppen A, Bolander-Gouaille C. Treatment of depression: time to consider folic acid and vitamin B12. J Psychopharmacology 2005;19(1):59-65.

9.        Lamers Y, Prinz-Langenohl R, Moser R, et al. Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women. Am J Clin Nutr 2004;79:473-78.

10.      Wu D, Pardridge WM. Blood-brain barrier transport of reduced folic acid. Pharm Res 1999;16(3):415-19.