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Negative Mood / Depression
The Cortisol Connection
SymphoraTM is formulated to promote a positive mood and mental well-being by beneficially modulating cerebral metabolism of the neurohormone cortisol. Designed to act centrally, within the brain, Symphora features 5-methyl tetrahydrofolate-which research suggests is able to pass the blood-brain barrier-along with DHEA and vitamin
D for targeted neurological support. Patient benefits:
- Cortisol is a glucocorticoid hormone associated with mood, well-being, and stress response
- Features DHEA, which research suggests may support a positive mood by modulating the effects of brain
cortisol during periods of stress
- Provides vitamin D, a vitamin that has been associated with serotonin metabolism and a positive mood
- Supplies neuroactive vitamin B12 and folate-cofactors in the synthesis of neurotransmitters such as
serotonin
Serotonin Function
Somnolin® is designed to support a positive mood and an alert, relaxed state during the day, while promoting recuperative sleep at night through beneficially modulating the metabolism of serotonin. This formula features clinically effective levels of 5-HTP and theanine in just one tablet daily.
Serotonin Uptake
St. John's Wort with ActiFolate and B12 is formulated to support a calm, positive mood with nutrients that may play a role in serotonin metabolism. This formula supplies clinically effective levels of standardized St. John's Wort leaf and flower extract combined with a bioactive folate blend and vitamin B12 in two tablets daily.
Suggested Nutritional Supplementation
- SymphoraTM - Two tablets daily
Symphora is formulated to promote a positive mood and mental well-being by beneficially modulating
cerebral metabolism of the neurohormone cortisol.
- Somnolin® - 2-4 Tablets daily
Somnolin features a complementary blend of nutrients, including 5-HTP, theanine, and targeted B
vitamins, to promote a restful, relaxed state and relieve occasional sleeplessness.
- St. John's Wort - 1-2 Tablets daily
St. John's Wort contains 450 mg of a premium extract of St. John's wort standardized to 0.3% hypericins, combined with folates and vitamin B12.
- Appropriate Wellness EssentialsTM formula - 1-2 packets daily
Key Vitamins & Minerals, Essential Fatty Acids, PLUS Patient Specific Nutrition.
Recommended uses:
- Positive mood support
- Feeling of well-being support
WARNING: DO NOT USE IF PREGNANT OR NURSING. For adult use only. Avoid use if patient has, or has
a history of hormone related cancer, diabetes, or bipolar disorder. If patient has a medical condition or takes
medication use with caution. Do not exceed recommended dosage.
Refrences:
1. Kimonides VG, Khatibi NH, Svendsen CN, et al. Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acidinduced neurotoxicity. Proc Natl Acad Sci USA 1998;95:1852-57.
2. Wolkowitz OM, Reus VI, Keebler A, et al. Double-blind treatment of major depression with dehydroepiandrosterone. Am J Psychiatry 1999;156(4):646-49.
3. Strous RD, Maayan R, Lapidus R, et al. Dehydroepiandrosterone augmentation in the management of negative, depressive, and anxiety symptoms in schizophrenia. Arch Gen Psychiatry 2003;60(2):133-41.
4. Lansdowne AT, Provost SC. Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology (Berl.) 1998;135(4):319-23.
5. Taniura H, Ito M, Sanada N, et al. Chronic D3 treatment protects against neurotoxicity by glutamate in association with upregulation of vitamin D receptor mRNA expression in cultured rat cortical neurons. J Neurosci Res 2006;83:1179-89.
6. Bottiglieri T, Laundy M, Crellin R, et al. Homocysteine, folate, methylation, and monoamine metabolism in depression. J Neurol Neurosurg Psychiatry 2000;69:228-32.
7. Wu D, Pardridge WM. Blood-brain barrier transport of reduced folic acid. Pharm Res 1999;16(3):415-19.
8. Spector R, Lorenzo AV. Folate transport in the central nervous system. Am J Physiol 1975;229(3):777-82.
9. Quadri P, Fragiacomo C, Pezzati R, et al. Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia. Am J Clin Nutr 2004;80:114-22.
10. Coppen A, Bolander-Gouaille C. Treatment of depression: time to consider folic acid and vitamin B12. J Psychopharmacology 2005;19(1):59-65.