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Occasional Sleeplessness / Sleep Disorders
Melatonin Function
BenesomTM is formulated to promote a restful, relaxed state and relieve occasional sleeplessness by beneficially modulating the metabolism of melatonin and GABA. Designed to act centrally, within the brain, Benesom features supplemental melatonin-which research suggests is able to cross the blood-brain barrier. LactiumPureTM-a patented, bioactive decapeptide with relaxing properties-and passionflower are added to round out this formula
for targeted neurological support.
Patient benefits:
- Promotes restful, quality sleep for those with occasional sleeplessness
- Features melatonin, a hormone naturally produced in the brain that helps regulate sleep,waking, and the body's circadian rhythm (or time clock)
- Provides LactiumPureTM and passion flower, which may favorably modulate the metabolism of GABA
Suggested Nutritional Supplementation
- BenesomTM - One tablet one hour before bedtime. A typical consumption range for melatonin is 1 mg - 3
mg for supporting occasional sleeplessness.
Benesom is formulated to promote a restful, relaxed state and relieve occasional sleeplessness by beneficially modulating the metabolism of melatonin and GABA.
- Tran-Q® - 2-6 tablets daily
Tran-Q has been traditionally used to maintain a calm spirit, relax the body, and quiet the heart. According
to traditional Chinese herbology, a sustained intense emotional state causes a disharmony between liver
and heart energy resulting in nervousness and mild mood changes.
- LuminaTM - 2-4 softgels daily
Lumina is designed to support healthy mental function and relaxation-issues related to proper focus, attention, learning, and memory-through modulating the metabolism of neurotransmitters such as dopamine, gamma-aminobutyric acid (GABA), and norepinephrine.
Recommended uses:
- Occasional sleeplessness
CAUTION: Do not use if pregnant or nursing. For adult use only. Avoid use if patient has a history of seizures or depression, is taking benzodiazepine or sedating medication, or is consuming alcohol. Use with caution if taking antiocoagulants or other medications or if operating machinery. Not recommended for more than 2 consecutive months.
Refrences:
1. Zhdanova IV, Wurtman RJ, Regan MM, et al. Melatonin treatment for age-related insomnia. J Clin Endocrinol Metab 2001;86:4727- 30.
2. Smits MG, van Stel HF, van der Heijden K, et al. Melatonin improves health status and sleep in children with idiopathic chronic sleep-onset insomnia: a randomized placebo-controlled trial. J Am Acad Child Adolesc Psychiatry 2003;42(11):1286-93.
3. van den Berg MP, Merkus P, Romeijin SG, et al. Uptake of melatonin into the cerebrospinal fluid after nasal and intravenous delivery: studies in rats and comparison with a human study. Pharm Res 2004;21(5):799-802.
4. Pardridge WM, Mietus LJ. Transport of albumin-bound melatonin through the blood-brain barrier. J Neurochem 1980;34(6):1761-63.
5. Hardeland R. Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance. Endocrine 2005;27(2):119-30.
6. Akhondzadeh S, Naghavi HR, Vazirian M, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001;26:363-67.
7. Dhawan K, Kumar S, Sharma A. Anti-anxiety studies on extracts of Passiflora incarnata Linneaus. J Ethnopharmacol 2001;78:165- 70.
8. Messaoudi M, Lefranc-Millot C, Desor D, et al. Effects of a tryptic hydrolysate from bovine milk alphaS1-casein on hemodynamic responses in healthy human volunteers facing successive mental and physical stress situations. Eur J Nutr 2005;44(2):128-32.
9. Guesdon B, Messaoudi M, Lefranc-Millot C, et al. A tryptic hydrolysate from bovine milk alphaS1-casein improves sleep in rats subjected to chronic mild stress. Peptides 2006;27(6):1476-82.
10. Campbell EL, Chebib M, Johnston GA. The dietary flavonoids apigenin and (-)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA(A) receptors. Biochem Pharmacol 2004;68(8):1631-38.