Suggested Nutritional Supplementation

 

  • Fibroplex - 2 tablets 4 times daily for one week; then 2 tablets 2 times daily for 7 weeks.

Nutritional support for neuromuscular function.

  • Mitochondrial Resuscitate - 1-2 capsules 3 times daily in between meals.

Support for cellular energy production.

  • 5 Hydroxytryptophan Extra Strength - 1-2 tablets twice daily in between meals.

5HTP is the precursor to seritonin, altered seritonin levels have been associated with fibromyalgia.

  • AdvaClear and UltraInflamX - Bifunctional Detoxification with nutritional support for inflammation. (see

Detoxification section).

  • Endefen - 2 tablespoons twice daily for the repair and enhance the GI immune system function

Multi-dimensional support for GI health.

  • Ultra Flora Plus DF - mix ¼- ½ teaspoon twice daily mixed with Endefen.

Dairy-free advanced probiotic nutrition with fructooligosaccharides.

  • DHEA - 1-2 capsules two times daily.

DHEA deficiency is common in fibromyalgia patients.  DHEA is a 99.5% pure pharmaceutical grade food supplement  in

a hypoallergenic rice starch base.

 

If patient has sleep disturbance add:

  • BenesomTM - One tablet one hour before bedtime

Benesom is formulated to promote a restful, relaxed state and relieve occasional sleeplessness by beneficially modulating the metabolism of melatonin and GABA.

 

Dietary Suggestions

FirstLine Therapy® Diet

Can  monosodium  glutamate  trigger fibromyalgia?    Four  women  with  fibromyalgia  (duration  of  illness,

2-17  years) who had previously received multiple treatments with limited success had complete or nearly complete  resolution  of  their  symptoms  within  months  after  eliminating  monosodium  glutamate  (MSG)  or MSG  plus  aspartame  from  their diet.    In  each  patient,  symptoms  recurred whenever MSG was ingested. Comment: MSG and aspartate (one of the two amino acids present in aspartame) acts as excitatory neurotransmitters, and can lead to neurotoxicity when used in excess. Research suggests that MSG alone, or MSG plus aspartame, may be a cause of symptoms in some patients with fibromyalgia.   Because neither MSG nor aspartame is a necessary component of the diet, a therapeutic trial of avoiding these substances seems worthwhile for patients with fibromyalgia.

 

Additional Considerations

Frequency  specific microcurrent  has  also been  clinically effective  in managing  pain associated  with fibromyalgia.

 

Fibromyalgia References

1.        National Institute of Arthritis and Musculoskeletal Skin Diseases.  National Institutes of Health.  Fibromyalgia.  Retrieved July 2, 2002 from http://www.niams.gov/hi/topics/fibromyalgia/fibrifs.htm

2.        Arthritis Foundation Disease Center.  Fibromyalgia Retrieved July 22, 2002 from http://www.arthritis.org/conditions/DiseaseCenter/fibromyalgia/asp

3.        Horrocks LA, Yeo, YK.  Health benefits of docosahexaenoic (DHA). Pharmacol Rs 1999;40(3):211-25.

4.        Kwong LK, Kamzalov S, Rebrin I, et al.  Effects of coenzyme Q(10) administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat.  Free Radic Biol Med 2002;33(5):627-38.

5.        Dlugosz A, Piotrowska D.  Lipid peroxidation stimulated by Solvesso, Bawanol and methanol, and its counteraction by antioxidants in human placental mitochondria.  Toxicol In Vitro 2002;16(6):649-56.

6.        Custodio JB, Carduso CM, Almeida LM.  Thiol protecting agents and antioxidants inhibit the mitochondrial permeability transision promoted by etoposide: implications in the prevention of etoposide-induced apoptosis.  Chem Biol Interact 2002;140(2):169-84.

7.        Nakai A, Shibazaki Y, Taniuchi Y, et al.  Vitamins ameliorate secondary mitochondrial failure in neonatal rat brain.  Pediatr Neurol 2002;27(1):30-35.

8.        Werbach MR.  Nutritional strategies for treating chronic fatigue syndrome.  Altern Med Rev 2000;5(2)93-108.

9.        Abraham GE, Flechas JD.  Management of fibromyalgia: rationale for the use of magnesium and malic acid.  J Nutr Med 1992;3:49-59.

10.     Nagle FJ, Balke B, Ganslen R et al.  The mitigation of physical fatigue with "spartase".  FAA Office of Aerospace Medicine 1963;63-12:1-10.

11.     Ahlborg B, Ekelund LG, Nilsson CG.  Effect of potassium-magnesium-aspartate on the capacity for prolonged exercise in man. Acta Physiol Scand 1968;74:238-45.

12.     Littlejohn GO, Walker J.  A realistic approach to managing patients with fibromyalgia.  Curr Rheumatol Rep 2002;4(4):286-92.

13.     Dessein PH, Shipton EA, Joffe BI et al Hyposecretion of adrenal androgens and the relation of serum adrenal steroids, serotonin and insulin-like growth factor-1 to clinical features in women with fibromyalgia.  Pain 1999;83(2):313-19.

14.     Demitrack MA, Crofford LJ.  Evidence for and pathophysical implications of hypothalamic-pituitary-adrenal axis dysregulation in fibromyalgia and chronic fatigue syndrome.  Ann NY Acad Sci 1998;840:684-97.

15.     Wolfe F.  The clinical syndrome of fibrositis.  Am J Med 1986;81:7-13.

16.     Masi AT, Yunus MB.  Concepts of illness in populations as applied to fibromyalgia syndromes.  Am J Med 1986;81:19-25.

17.     Smythe HA.  Nonarticular Rheumatism and Psychogenic Musculo-skeletal Syndromes.  In:McCarty DJ, ed. Arthritis and Allied Conditions.  9th  ed. Philadelphia: Lea

18.     Goldenberg DL, Simms RW, Greiger A, et al.  High frequency of fibromyalgia in patients with chronic fatigue seen in a primary care practice.  Arthritis Rheum 1990;33:381-87.

19.     Campbell SM, Clarks, Tindall, EA, et al. Clinical characteristics of fibrositis.  A blinded controlled study of symptoms and tender points.  Arthritis Rheum 1983;26:817-24.

20.     Henrickson KG, Bengston A.  Fibromyalgia-a clinical entity? Can J Physiol Pharmacol 1991;69:692-77.

21.     Sen P, Maiti PC, Puri S, et al.  Mechanism of anti-stress activity of Ocimum sanctum Linn, eugenol and Tinospora malabarica in experimental animals.  Indian J Exp Biol 1992;30(7):592-96.

22.     Mishra LC, Singh BB, Dagenais S.  Scientific basis for the therapeutic use of Withania somnifera (ashwaganda): a review. Altern Med Rev 2000;5(4):334-46.

23.     Singh A, Saxena E, Bhutani KK.  Adrenocorticosterone alterations in male, albino mice treated with Trichopus zeylanicus, Withania somnifera, and Panax ginseng preparations.  Phytother Res 2000;14(2):122-25.

24.     Singh HK, Rastogi RP, Srimal RC, et al.  Effect of bacosides A and B on avoidance responses in rats.  Phytother Res 1998;2(2):70-75.

25.     Fidanaza A, Floridi S, Lenti L.  Panthenol and glucocorticoids.  Boll Soc Ital Biol Sper 1981:57(18):1869-72.

26.    

6

Lau-Cam CA, Thadikonda KP, Kendall BF.  Stimulation of rat liver glycogenolysis by vitamin B :  a role for adrenal catecholamines.  Res Commun Chem Pathol Pharmacol 1991;73(2).

27.     Fidanaza A, Floridi S, Lenti L.  Panthenol and glucocorticoids.  Boll Soc Ital Biol Sper 1981;57(18):1869-72.

28.     Witchl M.  Herbal drugs and phytopharmaceuticals.  London:CRC Press;1989.

29.     Brown KM, Arthur JR.  Selenium, selenoproteins and human health: a review.  Public Health Nutr 2001;4(2B):593-99.

30.     Nishiyama S, Futagoishi-Suginohara Y, Matsukara M, et al.  Zinc supplementation alters thyroid hormone metabolism in disabled patients with zinc deficiency.  J Am Coll Nutr 1994;13(1):62-67.

31.     Gupta P, Kar A.  Cadmium induced thyroid dysfunction in chicken: hepatic type I iodothyronine 5'-monodeiodinase activity and role of lipid peroxidation.  Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 1999;123(1):39-44.

32.     Pallet V, Audouin-Chevallier I, Verret C, et al. Retinoic acid differentially modulates triiodothyronine and retinoic acid receptors in rat liver according to thyroid status. Eur J Endocrinol 1994;13(4):377-84.

33.     Shrader M, Muller KM, Nayeri S, et al.  Vitamin D3-thyroid hormone receptors heterodimer polarity directs ligand sensitivity of transactivation.  Nature 1994;370 (6488):382-86.

34.     Chang L.  The association of functional gastrointestinal disorders and fibromyalgia.  Eur J Surg Suppl 1998;583:32-36. Canataroðlu Y, Gümürdülu Y, Erdem A, et al.  Prevalence of fibromyalgia in patients with irritable bowel syndrome.  Turk J Gastroenterol 2001;12(12)141-44.

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